Anti-TREM1 antibody [RM0138-3C66] (ab86490)

Overview

  • Product nameAnti-TREM1 antibody [RM0138-3C66]
    See all TREM1 primary antibodies
  • Description
    Rat monoclonal [RM0138-3C66] to TREM1
  • SpecificityThis antibody detects mouse of TREM1, but not TREM2b in Western blotting.
  • Tested applicationsSuitable for: WB, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Mouse recombinant protein of the extracellular domain of TREM1

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein A purified
  • Purification notesThe IgG fraction of culture supernatant was purified by Protein A affinity chromatography.
  • ClonalityMonoclonal
  • Clone numberRM0138-3C66
  • IsotypeIgG2
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab86490 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 26 kDa.
IHC-Fr 1/50 - 1/100.

Target

  • FunctionStimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.
  • Tissue specificityHighly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.
  • Sequence similaritiesContains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Post-translational
    modifications
    Glycosylated.
  • Cellular localizationSecreted and Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD354 antibody
    • OTTMUSP00000018206 antibody
    • TREM 1 antibody
    • TREM-1 antibody
    • TREM1 antibody
    • TREM1_HUMAN antibody
    • Triggering receptor expressed on monocytes 1 antibody
    • Triggering receptor expressed on myeloid cells 1 antibody
    • Triggering receptor TREM 1 antibody
    • Triggering receptor TREM1 antibody
    see all

References for Anti-TREM1 antibody [RM0138-3C66] (ab86490)

ab86490 has not yet been referenced specifically in any publications.

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Thank you very much for your email and your interest and collaboration offer. Thank you also for your patience while I was investigating. Please find here the answers to your questions: 1.) Those two antibodies are different clones. The ab86490 is lcon...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"