Overview

  • Product nameAnti-TREML2 antibody
  • Description
    Rabbit polyclonal to TREML2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide from Human TREML2. (SwissProt Q5T2D2.)

  • Positive control
    • 721_B cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab74837 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 35 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • RelevanceTREML2 is a single-pass type I membrane protein, and it contains 1 Ig-like V-type (immunoglobulin-like) domain. It is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 and TREM2, but it has distinct structural and functional properties. TREML2 is expressed throughout B cell development in addition to being expressed on macrophages and neutrophils and is the only TREM molecule to be found on lymphocytes. TREML2 is expressed on B lineage cells early in development, and the highest level of expression is detected on those mature peripheral B cell subpopulations that are involved in the initial humoral immune response against bacterial pathogens. TREML2 is unique in that it lacks either the conserved transmembrane lysine residue or ITAM/ITIMs within its own cytoplasmic domain. Thus, TREML2 does not exhibit any of the features associated with classical tyrosine-based signaling. Monocytes in the bone marrow or peripheral blood do not express detectable levels of TREML2, but its expression is up-regulated in conjunction with differentiation into macrophages. TREML2 is present on neutrophils in the bone marrow as well as the periphery, and inflammatory stimuli result in a dramatic increase in the expression of TREML2 on these cells in vivo.
  • Cellular localizationCell membrane; Single-pass type I membrane protein.
  • Database links
  • Alternative names
    • C6orf76 antibody
    • Chromosome 6 open reading frame 76 antibody
    • FLJ13693 antibody
    • MGC149715 antibody
    • MGC149716 antibody
    • TLT 2 antibody
    • TLT2 antibody
    • TREM like transcript 2 antibody
    • Trem like transcript 2 protein antibody
    • Triggering receptor expressed on myeloid cells like 2 antibody
    • Triggering receptor expressed on myeloid cells like protein 2 antibody
    see all

Anti-TREML2 antibody images

  • Anti-TREML2 antibody (ab74837) at 1 µg/ml (in 5% skim milk / PBS buffer) + 721_B cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 35 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)

References for Anti-TREML2 antibody (ab74837)

ab74837 has not yet been referenced specifically in any publications.

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