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Function
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.
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Tissue specificity
Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney.
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Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
Contains 1 protein kinase domain.
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Cellular localization
Nucleus.
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Information by UniProt
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Database links
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Alternative names
- C20orf97 antibody
- Neuronal cell death inducible putative kinase antibody
- Neuronal cell death-inducible putative kinase antibody
- NIPK antibody
- p65 interacting inhibitor of NF-kappaB antibody
- p65-interacting inhibitor of NF-kappa-B antibody
- SINK antibody
- SKIP 3 antibody
- SKIP3 antibody
- TRB 3 antibody
- TRB-3 antibody
- TRB3 antibody
- TRIB 3 antibody
- Trib3 antibody
- TRIB3_HUMAN antibody
- Tribbles homolog 3 antibody
- Tribbles pseudokinase 3 antibody
- Tribbles3 antibody
see all