• Product nameAnti-TRIB3 antibody [EPR3150]
    See all TRIB3 primary antibodies
  • Description
    Rabbit monoclonal [EPR3150] to TRIB3
  • Tested applicationsSuitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide corresponding to residues in human TRIB3

  • Positive control
    • 293T lysates, untreated or treated with Ionomycin and TPA.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab75774 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 40 kDa (predicted molecular weight: 40 kDa).
  • Application notesIs unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • FunctionDisrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.
    • Tissue specificityHighest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney.
    • Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
      Contains 1 protein kinase domain.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • C20orf97 antibody
      • Neuronal cell death inducible putative kinase antibody
      • Neuronal cell death-inducible putative kinase antibody
      • NIPK antibody
      • p65 interacting inhibitor of NF-kappaB antibody
      • p65-interacting inhibitor of NF-kappa-B antibody
      • SINK antibody
      • SKIP 3 antibody
      • SKIP3 antibody
      • TRB 3 antibody
      • TRB-3 antibody
      • TRB3 antibody
      • TRIB 3 antibody
      • Trib3 antibody
      • TRIB3_HUMAN antibody
      • Tribbles homolog 3 antibody
      • Tribbles pseudokinase 3 antibody
      • Tribbles3 antibody
      see all

    Anti-TRIB3 antibody [EPR3150] images

    • All lanes : Anti-TRIB3 antibody [EPR3150] (ab75774) at 1/1000 dilution

      Lane 1 : 293T lysates, treated with Ionomycin and TPA
      Lane 2 : 293T lysates, untreated

      Lysates/proteins at 10 µg per lane.

      goat anti-rabbit HRP at 1/1000 dilution

      Predicted band size : 40 kDa
      Observed band size : 40 kDa

    References for Anti-TRIB3 antibody [EPR3150] (ab75774)

    ab75774 has not yet been referenced specifically in any publications.

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