Overview

  • Product name
    Trichostatin A
  • Description
    Potent, selective histone deacetylase inhibitor
  • Biological description
    Potent, selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces cell proliferation, differentiation and apoptosis in vitro. Anticancer and antifungal agent. Active in vivo and in vitro.
  • Purity
    > 98%

Properties

Images

  • Trichostatin A inhibits histone deacetylases in NIH/3T3 cells.

    Cells from logarithmic were incubated overnight with different concentrations of Trichostatin A (ab120850). Cell proteins were resolved by SDS-PAGE and probed with anti-acetylated histone antibodies.

References

This product has been referenced in:
  • Vigushin DM  et al. Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin Cancer Res 7:971-6 (2001). Read more (PubMed: 11309348) »
  • Suzuki T  et al. Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell lines. Int J Cancer 88:992-7 (2000). Read more (PubMed: 11093826) »
  • Yoshida M  et al. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 265:17174-9 (1990). Read more (PubMed: 2211619) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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