Overview

  • Product nameTriciribine
  • Description
    Selective, potent inhibitor of Akt activation
  • Alternative names
    • API 2
    • NSC 154020
    • TCN
  • Biological descriptionCell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation and signalling of Akt. Selective over PKC, PKA, SGK and p38 pathways. Induces cell growth arrest and apoptosis in vitro.
  • Purity> 98%

Properties

    References for Triciribine (ab120936)

    This product has been referenced in:
    • Gloesenkamp CR  et al. AKT inhibition by triciribine alone or as combination therapy for growth control of gastroenteropancreatic neuroendocrine tumors. Int J Oncol 40:876-88 (2012). Read more (PubMed: 22075556) »
    • Yang L  et al. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res 64:4394-9 (2004). Read more (PubMed: 15231645) »
    • Wotring LL  et al. Dual mechanisms of inhibition of DNA synthesis by triciribine. Cancer Res 50:4891-9 (1990). Read more (PubMed: 2379153) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"