• Product name
  • Description
    Rabbit polyclonal to TRIM11
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-155 of Human TRIM11.

  • Positive control
    • 293T, A431, Jurkat and Raji whole cell lysates; Human Hepatoma tissue.



Our Abpromise guarantee covers the use of ab111694 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/500 - 1/3000. Predicted molecular weight: 53 kDa.


  • Function
    E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
  • Tissue specificity
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 B30.2/SPRY domain.
    Contains 1 RING-type zinc finger.
  • Domain
    The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6 (By similarity). They are also involved in MED15-binding.
    The B30.2 domain may be involved cellular protein quality control by promoting the degradation of insoluble ubiquitinated proteins.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • BIA 1 antibody
    • BIA1 antibody
    • E3 ubiquitin protein ligase TRIM11 antibody
    • E3 ubiquitin-protein ligase TRIM11 antibody
    • Protein BIA1 antibody
    • RING finger protein 92 antibody
    • RING type E3 ubiquitin transferase TRIM11 antibody
    • RNF 92 antibody
    • RNF92 antibody
    • TRI11_HUMAN antibody
    • Trim 11 antibody
    • TRIM11 antibody
    • Tripartite motif containing 11 antibody
    • tripartite motif protein 11 antibody
    • Tripartite motif-containing protein 11 antibody
    see all


  • Anti-TRIM11 antibody (ab111694) at 1/2000 dilution + Jurkat whole cell lysate at 30 µg

    Predicted band size : 53 kDa
  • ab111694 at 1/500 dilution staining TRIM11 in Formalin-fixed, paraffin-embedded Human Hepatoma tissue by Immunohistochemistry.


This product has been referenced in:
  • Chen Y  et al. Proliferation and invasion of ovarian cancer cells are suppressed by knockdown of TRIM11. Oncol Lett 14:2125-2130 (2017). Read more (PubMed: 28781653) »

See 1 Publication for this product

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