Anti-TRIM11 antibody - C-terminal (ab171641)

Overview

  • Product name
    Anti-TRIM11 antibody - C-terminal
    See all TRIM11 primary antibodies
  • Description
    Rabbit polyclonal to TRIM11 - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human TRIM11 aa 299-330 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q96F44

  • Positive control
    • HepG2 cell line lysate, Human heart tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab171641 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/100 - 1/500. Predicted molecular weight: 53 kDa.

Target

  • Function
    E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
  • Tissue specificity
    Ubiquitous.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 B30.2/SPRY domain.
    Contains 1 RING-type zinc finger.
  • Domain
    The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6 (By similarity). They are also involved in MED15-binding.
    The B30.2 domain may be involved cellular protein quality control by promoting the degradation of insoluble ubiquitinated proteins.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • BIA 1 antibody
    • BIA1 antibody
    • E3 ubiquitin protein ligase TRIM11 antibody
    • E3 ubiquitin-protein ligase TRIM11 antibody
    • Protein BIA1 antibody
    • RING finger protein 92 antibody
    • RING type E3 ubiquitin transferase TRIM11 antibody
    • RNF 92 antibody
    • RNF92 antibody
    • TRI11_HUMAN antibody
    • Trim 11 antibody
    • TRIM11 antibody
    • Tripartite motif containing 11 antibody
    • tripartite motif protein 11 antibody
    • Tripartite motif-containing protein 11 antibody
    see all

Images

  • Anti-TRIM11 antibody - C-terminal (ab171641) at 1/100 dilution + HepG2 cell line lysate at 35 µg

    Predicted band size: 53 kDa

  • Immunohistochemical analysis of paraffin embedded Human heart tissue labeling TRIM11 with ab171641 at 1/10 followed by peroxidase conjugation of the secondary antibody and DAB staining.

References

ab171641 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab171641.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up