• Product name
  • Description
    Rabbit polyclonal to TRIM27
  • Host species
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 220-513 of Human TRIM27 (Uniprot IDP14373)

  • Positive control
    • NT2D1 and SK-N-SH whole cell lysates; Human colon cancer tissue


  • Form
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 78% PBS, 20% Glycerol, 1% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab154931 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 58 kDa.
IHC-P 1/100 - 1/1000.


  • Function
    Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA (By similarity). E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation.
  • Tissue specificity
    Expressed in testis namely within the seminiferous tubules.
  • Involvement in disease
    Defects in TRIM27 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving TRIM27/RFP is found in thyroid papillary carcinomas. Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta TRIM27/RET oncogenes.
  • Sequence similarities
    Belongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 B30.2/SPRY domain.
    Contains 1 RING-type zinc finger.
  • Domain
    The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6.
  • Cellular localization
    Nucleus. Cytoplasm. Nucleus > PML body. Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies.
  • Information by UniProt
  • Database links
  • Alternative names
    • AW538890 antibody
    • DAAP-182E11.3 antibody
    • MGC189472 antibody
    • OTTHUMP00000029314 antibody
    • Ret finger protein antibody
    • RFP antibody
    • RFP transforming protein antibody
    • Rfp1 antibody
    • RING finger protein 76 antibody
    • RNF76 antibody
    • TRI27_HUMAN antibody
    • TRIM 27 antibody
    • Trim27 antibody
    • Tripartite motif containing 27 antibody
    • Tripartite motif containing protein 27 antibody
    • Tripartite motif protein TRIM27 antibody
    • Tripartite motif-containing protein 27 antibody
    • Zinc finger protein RFP antibody
    see all


  • All lanes : Anti-TRIM27 antibody (ab154931) at 1/1000 dilution

    Lane 1 : NT2D1 whole cell lysate
    Lane 2 : SK-N-SH whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 58 kDa

    7.5% SDS PAGE
  • Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue, labeling TRIM27 with ab154931 at 1/500 dilution.


ab154931 has not yet been referenced specifically in any publications.

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