This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

Overview

Properties

Associated products

Applications

  • Application notesWB: Preliminary experiments gave no signal but low background in Human Testis and Placenta extracts at up to 1µg/ml.
    Tested in peptide ELISA, antibody detection limit dilution 1/64000.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionE3 ubiquitin-protein ligase.
    • Tissue specificityUbiquitous.
    • PathwayProtein modification; protein ubiquitination.
    • Involvement in diseaseDefects in TRIM37 are the cause of mulibrey nanism (MUL) [MIM:253250]; also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common.
    • Sequence similaritiesBelongs to the TRIM/RBCC family.
      Contains 1 B box-type zinc finger.
      Contains 1 MATH domain.
      Contains 1 RING-type zinc finger.
    • Post-translational
      modifications
      Auto-ubiquitinated.
    • Cellular localizationCytoplasm > perinuclear region. Peroxisome. Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation.
    • Information by UniProt
    • Database links
    • Alternative names
      • E3 ubiquitin protein ligase TRIM37 antibody
      • E3 ubiquitin-protein ligase TRIM37 antibody
      • KIAA0898 antibody
      • MUL antibody
      • MUL protein antibody
      • Mulibrey nanism gene antibody
      • Mulibrey nanism protein antibody
      • POB 1 antibody
      • POB1 antibody
      • RING B box coiled coil protein antibody
      • TEF 3 antibody
      • TEF3 antibody
      • TRI37_HUMAN antibody
      • TRIM 37 antibody
      • Trim37 antibody
      • Tripartite motif containing 37 antibody
      • Tripartite motif containing 37 protein antibody
      • Tripartite motif containing protein 37 antibody
      • Tripartite motif-containing protein 37 antibody
      see all

    References for Anti-TRIM37 antibody (ab13619)

    ab13619 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your enquiry. Ab13619 is a Fast-Track antibody; Fast-Track antibodies are antibodies that are still in development and are immunogen affinity purified and are shown by ELISA to have high titre values against their immunogen. We are curren...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"