Overview

  • Product name
  • Description
    Rabbit polyclonal to TRIM37
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide contain a sequence corresponding to a region within amino acids 902 and 964 of TRIM37

  • Positive control
    • Raji whole cell lysate; HeLa cells

Properties

Applications

Our Abpromise guarantee covers the use of ab95997 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 108 kDa.
ICC/IF 1/100 - 1/200.

Target

  • Function
    E3 ubiquitin-protein ligase.
  • Tissue specificity
    Ubiquitous.
  • Pathway
    Protein modification; protein ubiquitination.
  • Involvement in disease
    Defects in TRIM37 are the cause of mulibrey nanism (MUL) [MIM:253250]; also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common.
  • Sequence similarities
    Belongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 MATH domain.
    Contains 1 RING-type zinc finger.
  • Post-translational
    modifications
    Auto-ubiquitinated.
  • Cellular localization
    Cytoplasm > perinuclear region. Peroxisome. Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation.
  • Information by UniProt
  • Database links
  • Alternative names
    • E3 ubiquitin protein ligase TRIM37 antibody
    • E3 ubiquitin-protein ligase TRIM37 antibody
    • KIAA0898 antibody
    • MUL antibody
    • MUL protein antibody
    • Mulibrey nanism gene antibody
    • Mulibrey nanism protein antibody
    • POB 1 antibody
    • POB1 antibody
    • RING B box coiled coil protein antibody
    • TEF 3 antibody
    • TEF3 antibody
    • TRI37_HUMAN antibody
    • TRIM 37 antibody
    • Trim37 antibody
    • Tripartite motif containing 37 antibody
    • Tripartite motif containing 37 protein antibody
    • Tripartite motif containing protein 37 antibody
    • Tripartite motif-containing protein 37 antibody
    see all

Images

  • Anti-TRIM37 antibody (ab95997) at 1/1000 dilution + Raji whole cell lysate at 30 µg

    Predicted band size : 108 kDa
  • ab95997, at 1/200 dilution, staining TRIM37 in paraformaldehyde-fixed HeLa cells by Immunofluorescence (Top), and merged with the DNA probe (Bottom).

References

This product has been referenced in:

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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