Overview

  • Product nameAnti-TRIM5 gamma antibody
    See all TRIM5 gamma primary antibodies
  • Description
    Rabbit polyclonal to TRIM5 gamma
  • Tested applicationsSuitable for: IHC-P, ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (Human) (C terminal).

  • Positive control
    • Human bladder and colon cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab17203 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 2 µg/ml.
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 35 kDa.

Target

  • FunctionIsoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesBelongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 B30.2/SPRY domain.
    Contains 1 RING-type zinc finger.
  • DomainThe RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
  • Post-translational
    modifications
    Ubiquitinates itself in a RING finger- and UBE2D2-dependent manner (in vitro).
  • Cellular localizationCytoplasm > P-body. Cytoplasmic bodies.
  • Information by UniProt
  • Database links
  • Alternative names
    • RING finger protein 88 antibody
    • RNF88 antibody
    • TRIM5 antibody
    • TRIM5_HUMAN antibody
    • Tripartite motif containing 5 antibody
    • Tripartite motif protein TRIM5 antibody
    • Tripartite motif-containing protein 5 antibody
    see all

Anti-TRIM5 gamma antibody images

  • Immunofluorescence of TRIM5 gamma in Human bladder tissue with ab17203 at 20 ug/mL.

  • All lanes : Anti-TRIM5 gamma antibody (ab17203) at 2 µg/ml

    Lane 1 : Human bladder cell lysate
    Lane 2 : Human colon cell lysate


    Observed band size : 35 kDa (why is the actual band size different from the predicted?)
    Detection of TRIM5 gamma in human bladder (A) and colon (B) cell lysates. ab17203 used at 2 ug/ml. Band of ~35 kDa detected. 
  • ab17203 at 2µg/ml staining TRIM5 gamma in human bladder tissue by IHC

References for Anti-TRIM5 gamma antibody (ab17203)

ab17203 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab17203.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"