Overview

  • Product name
  • Description
    Rabbit polyclonal to TRIO
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence, corresponding to amino acids 2556-2678 of Human TRIO.

  • Positive control
    • Human duodenum tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab121273 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.
  • Tissue specificity
    Highly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney and lung.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 CRAL-TRIO domain.
    Contains 2 DH (DBL-homology) domains.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 2 PH domains.
    Contains 1 protein kinase domain.
    Contains 2 SH3 domains.
    Contains 4 spectrin repeats.
  • Domain
    The N-terminal DBL/GEF domain specifically catalyzes nucleotide exchange for RAC1, leading to the activation of Jun kinase and the production of membrane ruffles. The second DBL/GEF domain is an exchange factor for rhoa and induces the formation of stress fibers.
  • Post-translational
    modifications
    Phosphorylated on serine residue(s).
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • ARHGEF23 antibody
    • MEBAS antibody
    • MRD44 antibody
    • PTPRF-interacting protein antibody
    • tgat antibody
    • trio antibody
    • Trio Rho guanine nucleotide exchange factor antibody
    • TRIO_HUMAN antibody
    • Triple functional domain (PTPRF interacting) antibody
    • Triple functional domain protein antibody
    see all

Images

  • ab121273 at 1/50 dilution staining TRIO in Paraffin-embedded Human Duodenum tissue by Immunohistochemistry.

References

ab121273 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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According to the database of Uniprot, there are 5 different isoforms for Human TRIO. Based on the immunogen sequence of ab121273, it is expected that ab121273 can recognize isoform 1, 2, 3, 4. Below is The predic...

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