Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab12329 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 57.1 kDa.

Target

  • Function
    Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
  • Tissue specificity
    Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors.
  • Sequence similarities
    Belongs to the zyxin/ajuba family.
    Contains 3 LIM zinc-binding domains.
  • Domain
    The LIM zinc-binding domains mediate interaction with LPAR2 and with S.typhimurium protein sseI.
  • Post-translational
    modifications
    Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13.
  • Cellular localization
    Cytoplasm > cytoskeleton. Cell junction > focal adhesion. Nucleus. Cytoplasm. Shuttles between nucleus and cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • MGC10556 antibody
    • MGC10558 antibody
    • MGC29959 antibody
    • MGC3837 antibody
    • MGC4423 antibody
    • OIP-1 antibody
    • OIP1 antibody
    • OPA interacting protein 1 antibody
    • OPA-interacting protein 1 antibody
    • Thyroid hormone receptor interactor 6 antibody
    • Thyroid receptor interacting protein 6 antibody
    • Thyroid receptor-interacting protein 6 antibody
    • TR-interacting protein 6 antibody
    • TRIP-6 antibody
    • Trip6 antibody
    • TRIP6_HUMAN antibody
    • TRIP6i2 antibody
    • ZRP 1 antibody
    • ZRP-1 antibody
    • Zyxin-related protein 1 antibody
    see all

Images



  • Predicted band size : 57.1 kDa


    Samples: Nuclear extract (NE) from HeLa cells. Antibody: Affinity purified rabbit anti-TRIP6 antibody (ab12329) used at 0.3 µg/ml. Detection: Chemiluminescence with an exposure time of 30 minutes.

References

ab12329 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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