Overview

  • Product name
  • Description
    Rabbit polyclonal to TRIP6
  • Specificity
    Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Interacts with PTPN13.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    A synthetic peptide which represented a portion of human Thyroid TRIP6 encoded within exon 4.

  • Positive control

Properties

Applications

Our Abpromise guarantee covers the use of ab12330 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: 1/1000 - 1/10,000. Predicted molecular weight: 57.1 kDa (unprocessed precursor).

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
    • Tissue specificity
      Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors.
    • Sequence similarities
      Belongs to the zyxin/ajuba family.
      Contains 3 LIM zinc-binding domains.
    • Domain
      The LIM zinc-binding domains mediate interaction with LPAR2 and with S.typhimurium protein sseI.
    • Post-translational
      modifications
      Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13.
    • Cellular localization
      Cytoplasm > cytoskeleton. Cell junction > focal adhesion. Nucleus. Cytoplasm. Shuttles between nucleus and cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • MGC10556 antibody
      • MGC10558 antibody
      • MGC29959 antibody
      • MGC3837 antibody
      • MGC4423 antibody
      • OIP-1 antibody
      • OIP1 antibody
      • OPA interacting protein 1 antibody
      • OPA-interacting protein 1 antibody
      • Thyroid hormone receptor interactor 6 antibody
      • Thyroid receptor interacting protein 6 antibody
      • Thyroid receptor-interacting protein 6 antibody
      • TR-interacting protein 6 antibody
      • TRIP-6 antibody
      • Trip6 antibody
      • TRIP6_HUMAN antibody
      • TRIP6i2 antibody
      • ZRP 1 antibody
      • ZRP-1 antibody
      • Zyxin-related protein 1 antibody
      see all

    Images



    • Predicted band size : 57.1 kDa


      Samples: Nuclear extract (NE) from HeLa cells. Antibody: Affinity purified rabbit anti-TRIP6 antibody (ab12330) used at 0.3 µg/ml. Detection: Chemiluminescence with an exposure time of 30 minutes.

    References

    ab12330 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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