Overview

  • Product name
  • Description
    Mouse monoclonal to TRIP6
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: SEQCYQAPGG PEDRGPAWVG SHGVLQHTQG LPADRGGLRP GSLDAEIDLL SSTLAELNGG RGHASRRPDR QAYEPPPPPA YRTGSLKPNP ASPLPASP, corresponding to amino acids 51-149 of Human TRIP6

  • Positive control
  • General notes

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

Properties

Applications

Our Abpromise guarantee covers the use of ab58373 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 50 kDa.
ICC/IF Use a concentration of 35 µg/ml.

Target

  • Function
    Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
  • Tissue specificity
    Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors.
  • Sequence similarities
    Belongs to the zyxin/ajuba family.
    Contains 3 LIM zinc-binding domains.
  • Domain
    The LIM zinc-binding domains mediate interaction with LPAR2 and with S.typhimurium protein sseI.
  • Post-translational
    modifications
    Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13.
  • Cellular localization
    Cytoplasm > cytoskeleton. Cell junction > focal adhesion. Nucleus. Cytoplasm. Shuttles between nucleus and cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • MGC10556 antibody
    • MGC10558 antibody
    • MGC29959 antibody
    • MGC3837 antibody
    • MGC4423 antibody
    • OIP-1 antibody
    • OIP1 antibody
    • OPA interacting protein 1 antibody
    • OPA-interacting protein 1 antibody
    • Thyroid hormone receptor interactor 6 antibody
    • Thyroid receptor interacting protein 6 antibody
    • Thyroid receptor-interacting protein 6 antibody
    • TR-interacting protein 6 antibody
    • TRIP-6 antibody
    • Trip6 antibody
    • TRIP6_HUMAN antibody
    • TRIP6i2 antibody
    • ZRP 1 antibody
    • ZRP-1 antibody
    • Zyxin-related protein 1 antibody
    see all

Anti-TRIP6 antibody images



  • Predicted band size : 50 kDa
    TRIP6 antibody (ab58373) at 1ug/lane + HeLa cell lysate at 25ug/lane.
  • ab58373 at 35 ug/ml staining TRIP6 in human Hella cells by Immunocytochemistry/ Immunofluorescence.

References for Anti-TRIP6 antibody (ab58373)

ab58373 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab58373.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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