Triptolide from Tripterygium wilfordii (ab120720)

Overview

  • Product name
    Triptolide from Tripterygium wilfordii
  • Description
    Anti-inflammatory agent with multiple biological activities
  • Alternative names
    • PG490
  • Biological description
    Active ingredient of the vineTripterygium wilfodii Hook. f. Anti-inflammatory and immunosuppressive agent. Inhibits NF-κB transcriptional activity. Additionally, shows antiproliferative and pro-apoptotic activites. Downregulates RAC1, JAK/STAT 3 pathway and has anticancer properties.
  • Purity
    > 99%

Properties

Applications

Our Abpromise guarantee covers the use of ab120720 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.

Images

  • ab22758 staining nucleolin in HeLa cells treated with Triptolide from Tripterygium wilfordii (ab120720), by ICC/IF. Changes in nuclear localization of nucleolin correlates with increased concentration of Triptolide from Tripterygium wilfordii, as described in literature.
    The cells were incubated at 37°C for 24h in media containing different concentrations of ab120720 (Triptolide from Tripterygium wilfordii ) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab22758 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

References

This product has been referenced in:
  • Graziose R  et al. Merging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and functional foods. Curr Drug Discov Technol 7:2-12 (2010). Read more (PubMed: 20156139) »
  • Wang Z  et al. Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression. Exp Mol Med 41:717-27 (2009). Read more (PubMed: 19561401) »
  • Yinjun L  et al. Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells. Leuk Res 29:99-105 (2005). Read more (PubMed: 15541481) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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