Overview

  • Product nameAnti-TrkC antibody
    See all TrkC primary antibodies
  • Description
    Goat polyclonal to TrkC
  • SpecificityThis antibody is specific for rat TrkC at 145kDa and an additional band at approximately 100kDa.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Chicken, Pig
  • Immunogen

    Recombinant entire extracellular domain of rat TrkC receptor, corresponding to aa1-429, expressed in COS cells.

  • Positive control
    • Mouse brain membrane protein preparation.

Properties

Applications

Our Abpromise guarantee covers the use of ab33656 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 145 kDa (predicted molecular weight: 68 kDa).

Target

  • FunctionReceptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
  • Tissue specificityWidely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 2 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Ligand-mediated auto-phosphorylation.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • EC 2.7.10.1 antibody
    • ETS related protein neurotrophic receptor tyrosine kinase fusion antibody
    • ETS related protein neurotrophic receptor tyrosine kinase fusion protein antibody
    • ETV6 NTRK3 fusion antibody
    • GP145 TrkC antibody
    • gp145(trkC) antibody
    • GP145-TrkC antibody
    • GP145TrkC antibody
    • Neurotrophic tyrosine kinase receptor type 3 antibody
    • Neurotrophin 3 receptor antibody
    • NT 3 growth factor receptor antibody
    • NT 3 growth factor receptor precursor antibody
    • NT 3 receptor antibody
    • NT-3 growth factor receptor antibody
    • Ntrk3 antibody
    • NTRK3_HUMAN antibody
    • OTTHUMP00000192915 antibody
    • TRK C antibody
    • Trk-C antibody
    • TRKC antibody
    • TrkC tyrosine kinase antibody
    • Tyrosine kinase receptor C antibody
    see all

References for Anti-TrkC antibody (ab33656)

ab33656 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. The immunogen for this product comprises the entire extracellular domain of rat TrkC receptor, corresponding to 1-429a.a, expressed in COS cells. Three isoforms of TrkC (isoforms A, B and C) differ in their amino aci...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"