Anti-Tropomyosin 1 (alpha) antibody (ab118875)

Overview

  • Product nameAnti-Tropomyosin 1 (alpha) antibody
    See all Tropomyosin 1 (alpha) primary antibodies
  • Description
    Rabbit polyclonal to Tropomyosin 1 (alpha)
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Cow, Pig
  • Immunogen

    Recombinant full length Human Tropomyosin 1 (alpha) protein.

  • Positive control
    • Human spleen and tonsil tissues; A431 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab118875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 33 kDa.
IHC-P Use a concentration of 10 µg/ml.

Target

  • FunctionBinds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
  • Tissue specificityDetected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle.
  • Involvement in diseaseDefects in TPM1 are the cause of cardiomyopathy familial hypertrophic type 3 (CMH3) [MIM:115196]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    Defects in TPM1 are the cause of cardiomyopathy dilated type 1Y (CMD1Y) [MIM:611878]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • Sequence similaritiesBelongs to the tropomyosin family.
  • DomainThe molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
  • Cellular localizationCytoplasm > cytoskeleton.
  • Information by UniProt
  • Database links
  • Alternative names
    • AA986836 antibody
    • AI854628 antibody
    • Alpha tropomyosin antibody
    • alpha-TM antibody
    • Alpha-tropomyosin antibody
    • C15orf13 antibody
    • cardiomyopathy, hypertrophic 3 antibody
    • CMD1Y antibody
    • CMH3 antibody
    • HTM alpha antibody
    • HTM-alpha antibody
    • OTTHUMP00000163688 antibody
    • sarcomeric tropomyosin kappa antibody
    • TM2 antibody
    • Tmpa antibody
    • TMSA antibody
    • Tpm-1 antibody
    • TPM1 antibody
    • TPM1_HUMAN antibody
    • tropomyosin 1 (alpha) antibody
    • tropomyosin 1 (alpha) isoform 1 antibody
    • tropomyosin 1 (alpha) isoform 2 antibody
    • tropomyosin 1 (alpha) isoform 3 antibody
    • tropomyosin 1 (alpha) isoform 4 antibody
    • tropomyosin 1 (alpha) isoform 5 antibody
    • tropomyosin 1 (alpha) isoform 6 antibody
    • tropomyosin 1 (alpha) isoform 7 antibody
    • Tropomyosin 1 antibody
    • Tropomyosin alpha 1 chain antibody
    • Tropomyosin alpha-1 chain antibody
    • Tropomyosin, skeletal muscle alpha antibody
    • Tropomyosin-1 antibody
    see all

Anti-Tropomyosin 1 (alpha) antibody images

  • Anti-Tropomyosin 1 (alpha) antibody (ab118875) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 33 kDa
  • ab118875, at 10 µg/ml, staining Tropomyosin 1 (alpha) in formalin fixed, paraffin embedded Human spleen tissue by Immunohistochemistry.
  • ab118875, at 10 µg/ml, staining Tropomyosin 1 (alpha) in formalin fixed, paraffin embedded Human tonsil tissue by Immunohistochemistry.

References for Anti-Tropomyosin 1 (alpha) antibody (ab118875)

ab118875 has not yet been referenced specifically in any publications.

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