• Product nameAnti-Tropomyosin 3 antibody
    See all Tropomyosin 3 primary antibodies
  • Description
    Mouse monoclonal to Tropomyosin 3
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-249 of Human Tropomyosin 3, with an enzyme tag. MW of the tag alone is 26 KDa.



Our Abpromise guarantee covers the use of ab76439 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesELISA: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Detects a band of approximately 53 kDa (predicted molecular weight: 33 kDa plus an enzyme tag).

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionBinds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
    • Involvement in diseaseDefects in TPM3 are the cause of nemaline myopathy type 1 (NEM1) [MIM:609284]. A form of nemaline myopathy with autosomal dominant or recessive inheritance. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. Autosomal dominant nemaline myopathy type 1 is characterized by a moderate phenotype with onset between birth and early second decade of life. Weakness is diffuse and symmetric with slow progression often with need for a wheelchair in adulthood. The autosomal recessive form has onset at birth with moderate-to-severe hypotonia and diffuse weakness. In the most severe cases, death can occur before 2 years. Less severe cases have delayed major motor milestones, and these patients may walk, but often need a wheelchair before 10 years.
      Defects in TPM3 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving TPM3 is found in thyroid papillary carcinomas. A rearrangement with NTRK1 generates the TRK fusion transcript by fusing the amino end of isoform 2 of TPM3 to the 3'-end of NTRK1.
    • Sequence similaritiesBelongs to the tropomyosin family.
    • DomainThe molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
    • Cellular localizationCytoplasm > cytoskeleton.
    • Information by UniProt
    • Database links
    • Alternative names
      • Alpha tropomyosin 3 antibody
      • Alpha tropomyosin slow skeletal antibody
      • CFTD antibody
      • Cytoskeletal tropomyosin TM30 antibody
      • FLJ41118 antibody
      • gamma TM antibody
      • Gamma tropomyosin antibody
      • Gamma-tropomyosin antibody
      • Heat stable cytoskeletal protein 30 kDa antibody
      • hscp30 antibody
      • hTM30nm antibody
      • hTM5 antibody
      • hTMnm antibody
      • MGC102590 antibody
      • MGC14582 antibody
      • MGC3261 antibody
      • MGC72094 antibody
      • NEM1 antibody
      • OK/SW-cl.5 antibody
      • OTTHUMP00000034019 antibody
      • OTTHUMP00000034171 antibody
      • OTTHUMP00000034172 antibody
      • TM 5 antibody
      • TM-5 antibody
      • TM3 antibody
      • TM30 antibody
      • TM30nm antibody
      • TM5 antibody
      • Tm5NM antibody
      • Tpm 5 antibody
      • TPM3 antibody
      • TPM3_HUMAN antibody
      • Tpm5 antibody
      • TPMsk3 antibody
      • TRK antibody
      • TRK ONCOGENE, INCLUDED antibody
      • Trop 5 antibody
      • Tropomyosin 3 antibody
      • Tropomyosin 3 gamma antibody
      • Tropomyosin 5 antibody
      • Tropomyosin alpha 3 chain antibody
      • Tropomyosin alpha-3 chain antibody
      • Tropomyosin gamma antibody
      • Tropomyosin-3 antibody
      • Tropomyosin-5 antibody
      see all

    Anti-Tropomyosin 3 antibody images

    • Anti-Tropomyosin 3 antibody (ab76439) at 1/500 dilution + immunogen at 0.1 µg

      Goat anti-mouse IgG (H&L)-HRP conjugate at 1/5000 dilution

      Predicted band size : 33 kDa
      Observed band size : 53 kDa (why is the actual band size different from the predicted?)

    References for Anti-Tropomyosin 3 antibody (ab76439)

    ab76439 has not yet been referenced specifically in any publications.

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