• Product nameAnti-Tropomyosin antibody [MAC 141]
    See all Tropomyosin primary antibodies
  • Description
    Rat monoclonal [MAC 141] to Tropomyosin
  • SpecificityAntibody reacts with tropomyosin in Lethocerus and Drosophila flight and non-flight muscle and with tropomyosin in flight muscles of all other insect species tested. Antibody reacts with Troponin H (TnH) in Lethocerus flight muscle, the 33 and 34 isoforms of TnH in Drosophila and proteins of TnH molecular weight in flight muscles of other Diptera and Lepidoptera. Antibody also reacts with tropomyosin in muscles of Crustacea and Caenorhabditis (nematode).
  • Tested applicationsSuitable for: WB, IHC-Fr, Electron Microscopy, ICC/IF, IHC - Wholemountmore details
  • Species reactivity
    Reacts with: Drosophila melanogaster, Lethocerus indicus (Waterbug)
    Predicted to work with: Caenorhabditis elegans, A wide range of other invertebrates
  • Immunogen

    Troponin-tropomyosin complex purified from Lethocerus indicus (Waterbug) flight muscle.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.1% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityMonoclonal
  • Clone numberMAC 141
  • IsotypeIgG1
  • Research areas


Our Abpromise guarantee covers the use of ab50567 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 54 kDa.
IHC-Fr Use at an assay dependent concentration. PubMed: 19272319
Electron Microscopy Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.
IHC - Wholemount Use at an assay dependent concentration. PubMed: 22841645


  • RelevanceTropomyosin is a dimeric coiled coil protein that binds along the length of actin filaments. It is associated with the thin filaments of muscle cells and the microfilaments of nonmuscle cells. Chicken embryo fibroblasts (CEF) contain five isoforms of tropomyosin (a, b, 1, 2, and 3), identified as such by their different apparent molecular masses after separation by SDS-PAGE, but similar biochemical properties, such as resistance to heat and organic solvents, the ability to bind to F actin filaments, and the lack of proline and tryptophan.
  • Cellular localizationCytoplasmic
  • Alternative names
    • Alpha tropomyosin antibody
    • Beta tropomyosin antibody
    • TM30nm antibody
    • TPM1 antibody
    • TPM2 antibody
    • TPM3 antibody
    • Tropomyosin 1 alpha antibody
    • Tropomyosin 1 antibody
    • Tropomyosin 2 antibody
    • Tropomyosin 2 beta antibody
    • Tropomyosin 3 antibody
    see all

Anti-Tropomyosin antibody [MAC 141] images

  • Immunohistochemical analysis of wholemount Drosohopila melanogaster embryo, staining Tropomyosin with ab50567 at 1/1000 dilution.
  • Immunohistochemical analysis of wholemount Drosohopila melanogaster embryo, staining Tropomyosin with ab50567 at 1/1000 dilution.

References for Anti-Tropomyosin antibody [MAC 141] (ab50567)

This product has been referenced in:
  • Williams J  et al. Noncanonical roles for Tropomyosin during myogenesis. Development 142:3440-52 (2015). IHC ; Drosophila melanogaster . Read more (PubMed: 26293307) »
  • Folker ES  et al. Translocating myonuclei have distinct leading and lagging edges that require kinesin and dynein. Development 141:355-66 (2014). Drosophila melanogaster . Read more (PubMed: 24335254) »

See all 8 Publications for this product

Product Wall

Thank you for your enquiry. I have been informed by the source of this product of the following information: " In 1993 Dr Matthew Colloff (Dept Bacteriology, Stobhill General Hospital, Glasgow) said that MAC 141 reacts with prawn tropomyosin. He ...

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