Overview

  • Product name
    Anti-TRP1 antibody [EPR13063]
    See all TRP1 primary antibodies
  • Description
    Rabbit monoclonal [EPR13063] to TRP1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WB, ICC/IFmore details
    Unsuitable for: IP
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    within Human TRP1 aa 50-150 (Cysteine residue). The exact sequence is proprietary.
    Database link: P17643

  • Positive control
    • Human melanoma lysate; B16-F0 cell lysate; Human skin tissue; B16-F0 cells.
  • General notes

    This antibody is unsuitable for IHC-P on mouse samples.

    Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab178676 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/250.

Unsuitable for IHC-P on mouse samples.

WB 1/10000 - 1/50000. Predicted molecular weight: 61 kDa.
ICC/IF 1/100 - 1/250.
  • Application notes
    Is unsuitable for IP.
  • Target

    • Function
      Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.
    • Tissue specificity
      Pigment cells.
    • Pathway
      Pigment biosynthesis; melanin biosynthesis.
    • Involvement in disease
      Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3) [MIM:203290]; also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair.
    • Sequence similarities
      Belongs to the tyrosinase family.
    • Cellular localization
      Melanosome membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • 5 antibody
      • 5,6 dihydroxyindole 2 carboxylic acid oxidase antibody
      • 6-dihydroxyindole-2-carboxylic acid oxidase antibody
      • b-PROTEIN antibody
      • CAS2 antibody
      • Catalase B antibody
      • CATB antibody
      • DHICA oxidase antibody
      • Glycoprotein 75 antibody
      • GP75 antibody
      • Melanoma antigen gp75 antibody
      • OCA3 antibody
      • TRP antibody
      • TRP-1 antibody
      • TRP1 antibody
      • Tyrosinase related protein 1 antibody
      • Tyrosinase-related protein 1 antibody
      • TYRP antibody
      • TYRP1 antibody
      • TYRP1_HUMAN antibody
      • TYRRP antibody
      see all

    Images

    • Anti-TRP1 antibody [EPR13063] (ab178676) at 1/10000 dilution + Human melanoma lysate at 10 µg

      Predicted band size: 61 kDa

    • Anti-TRP1 antibody [EPR13063] (ab178676) at 1/10000 dilution + B16-F0 cell lysate at 10 µg

      Predicted band size: 61 kDa

    • Immunohistochemical analysis of paraffin-embedded Human skin tissue labeling TRP1 with ab178676 at 1/100 dilution.

    • Immunofluorescent analysis of B16-F0 cells labeling TRP1 with ab178676 at 1/100 dilution.

    References

    This product has been referenced in:
    • Chaiprasongsuk A  et al. Photoprotection by dietary phenolics against melanogenesis induced by UVA through Nrf2-dependent antioxidant responses. Redox Biol 8:79-90 (2016). Read more (PubMed: 26765101) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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