Anti-TRP1 antibody [Ta99], prediluted (ab11781)

Overview

  • Product nameAnti-TRP1 antibody [Ta99], prediluted
    See all TRP1 primary antibodies
  • Description
    Mouse monoclonal [Ta99] to TRP1, prediluted
  • SpecificityThis monoclonal antibody detects a differentiation related, pigmentation-associated glycoprotein (gp75), expressed by melanoma cells, nomal melanocytes and nevi. This antibody does not react with carcinomas and sarcomas.
  • Tested applicationsSuitable for: IHC-Frmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    SK-MEL-23 Melanoma cell line

  • Positive control
    • Human melanoma or normal skin. Normal mouse serum is included with this product as a negative control.

Properties

Applications

Our Abpromise guarantee covers the use of ab11781 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr
  • Application notesIHC-Fr: Use at an assay dependent dilution. For optimal staining, the primary antibody should be incubated 20-60 minutes at room temperature.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionOxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.
    • Tissue specificityPigment cells.
    • PathwayPigment biosynthesis; melanin biosynthesis.
    • Involvement in diseaseDefects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3) [MIM:203290]; also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair.
    • Sequence similaritiesBelongs to the tyrosinase family.
    • Cellular localizationMelanosome membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • 5 antibody
      • 5,6 dihydroxyindole 2 carboxylic acid oxidase antibody
      • 6-dihydroxyindole-2-carboxylic acid oxidase antibody
      • b-PROTEIN antibody
      • CAS2 antibody
      • Catalase B antibody
      • CATB antibody
      • DHICA oxidase antibody
      • Glycoprotein 75 antibody
      • GP75 antibody
      • Melanoma antigen gp75 antibody
      • OCA3 antibody
      • TRP antibody
      • TRP-1 antibody
      • TRP1 antibody
      • Tyrosinase related protein 1 antibody
      • Tyrosinase-related protein 1 antibody
      • TYRP antibody
      • TYRP1 antibody
      • TYRP1_HUMAN antibody
      • TYRRP antibody
      see all

    References for Anti-TRP1 antibody [Ta99], prediluted (ab11781)

    ab11781 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"