Anti-TRPC1 antibody (ab110837)
Key features and details
- Goat polyclonal to TRPC1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-TRPC1 antibody
See all TRPC1 primary antibodies -
Description
Goat polyclonal to TRPC1 -
Host species
Goat -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Dog -
Immunogen
Synthetic peptide to an internal region of Human TRPC1 conjugated to KLH.
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Positive control
- Human cortex, Human Prostate (fibromuscular stroma)
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab110837 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. -
Tissue specificity
Seems to be ubiquitous. -
Sequence similarities
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
Contains 4 ANK repeats. -
Post-translational
modificationsActivation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 7220 Human
- Entrez Gene: 22063 Mouse
- Entrez Gene: 89821 Rat
- Omim: 602343 Human
- SwissProt: P48995 Human
- SwissProt: Q61056 Mouse
- SwissProt: Q9QX01 Rat
- Unigene: 250687 Human
see all -
Alternative names
- HTRP 1 antibody
- HTRP1 antibody
- MGC133334 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab110837 has been referenced in 1 publication.
- Zeng YZ et al. TRPC1 Inhibits Cell Proliferation/Invasion and Is Predictive of a Better Prognosis of Esophageal Squamous Cell Carcinoma. Front Oncol 11:627713 (2021). PubMed: 33854967