Overview

  • Product name
  • Description
    Goat polyclonal to TRPC1
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Dog
  • Immunogen

    Synthetic peptide to an internal region of Human TRPC1 conjugated to KLH.

  • Positive control
    • Human cortex, Human Prostate (fibromuscular stroma)

Properties

Applications

Our Abpromise guarantee covers the use of ab110837 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
  • Tissue specificity
    Seems to be ubiquitous.
  • Sequence similarities
    Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
    Contains 4 ANK repeats.
  • Post-translational
    modifications
    Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • HTRP 1 antibody
    • HTRP1 antibody
    • MGC133334 antibody
    • MGC133335 antibody
    • Mtrp1 antibody
    • Short transient receptor potential channel 1 antibody
    • Transient receptor potential canonical 1 antibody
    • Transient receptor potential cation channel subfamily C member 1 antibody
    • Transient receptor potential channel 1 antibody
    • Transient receptor protein 1 antibody
    • TRP 1 antibody
    • TRP 1 protein antibody
    • Trp related protein 1 antibody
    • TRP-1 antibody
    • TRP1 antibody
    • TRP1 protein antibody
    • TrpC1 antibody
    • Trpc1 transient receptor potential cation channel subfamily C member 1 antibody
    • TRPC1_HUMAN antibody
    • Trrp1 antibody
    see all

Images

  • ab110837 at 3.75 µg/ml staining TRPC1 in Human cortex by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
  • ab110837 at 3.75 µg/ml staining TRPC1 in Human Prostate (fibromuscular stroma) by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

References

ab110837 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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