Overview

  • Product nameAnti-TRPC4 antibody
    See all TRPC4 primary antibodies
  • Description
    Goat polyclonal to TRPC4
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse, Cow, Dog
  • Immunogen

    Synthetic peptide:

    C-KHAKEEDSSIDYD

    , corresponding to internal sequence amino acids 948-960 of Human TRPC4 (NP_057263.1).

  • Positive control
    • Rat Brain lysate; Human Placenta and kidney tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab111841 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 112 kDa.
IHC-P Use a concentration of 4.75 µg/ml.

Target

  • FunctionForm a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
  • Tissue specificityStrongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.
  • Sequence similaritiesBelongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily.
    Contains 4 ANK repeats.
  • DomainThe protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation.
    The calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) domain (695-724) is sufficient for the interaction with SESTD1.
    The spectrin-binding domain (730-758) is required for binding to SPTAN1 and SPTBN5.
  • Post-translational
    modifications
    Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with SLC9A3R1/NHERF.
  • Cellular localizationMembrane. Cell membrane. Enhanced insertion into the cell membrane after activation of the EGF receptor.
  • Information by UniProt
  • Database links
  • Alternative names
    • CCE1 antibody
    • HTRP 4 antibody
    • hTrp-4 antibody
    • hTrp4 antibody
    • MGC119570 antibody
    • MGC119571 antibody
    • MGC119572 antibody
    • MGC119573 antibody
    • RP11-10M8.1 antibody
    • Short transient receptor potential channel 4 antibody
    • STRPC4 antibody
    • Transient receptor potential 4 antibody
    • transient receptor potential cation channel subfamily C antibody
    • Transient receptor potential cation channel subfamily C member 4 antibody
    • transient receptor potential channel 4 antibody
    • TRP 4 antibody
    • trp related protein 4 antibody
    • Trp-related protein 4 antibody
    • TRP4 antibody
    • TRPC 4 antibody
    • TrpC4 antibody
    • TRPC4 protein antibody
    • TRPC4_HUMAN antibody
    see all

Anti-TRPC4 antibody images

  • ab111841, at 4.75µg/ml, staining TRPC4 in Formalin-fixed, Paraffin-embedded Human Kidney tissue by Immunohistochemistry.
  • ab111841, at 4.75µg/ml, staining TRPC4 in Formalin-fixed, Paraffin-embedded Human Placenta tissue by Immunohistochemistry.
  • Anti-TRPC4 antibody (ab111841) at 0.3 µg/ml + Rat Brain lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 112 kDa


    Exposure time : 1 hour

References for Anti-TRPC4 antibody (ab111841)

ab111841 has not yet been referenced specifically in any publications.

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