Anti-TRPC6 antibody (ab106840)

Overview

• Product name
  Anti-TRPC6 antibody
  See all TRPC6 primary antibodies
• Description
  Goat polyclonal to TRPC6
• Tested applications
  Suitable for: WBmore details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Cow, Pig
• Immunogen

  Synthetic peptide corresponding to Human TRPC6 aa 918-931 (C terminal).
  Sequence:

  C-EKLSMEPNQEETNR

  
  Database link: Q9Y210

  Run BLAST with Run BLAST with
• Positive control
  • Human placenta lysate

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage buffer
  Preservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
• Concentration information loading...
• Purity
  Immunogen affinity purified
• Purification notes
  ab106840 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Clonality
  Polyclonal
• Isotype
  IgG
• Research areas
  • Signal Transduction
  • Signaling Pathway
  • Calcium Signaling
  • Calcium Channels

  • Signal Transduction
  • Signaling Pathway
  • Calcium Signaling
  • Other

Associated products

• Compatible Secondaries
  • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
  • Donkey Anti-Goat IgG H&L (HRP) (ab205723)

Applications

Target

• Function
  Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
• Tissue specificity
  Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.
• Involvement in disease
  Defects in TRPC6 are the cause of focal segmental glomerulosclerosis type 2 (FSGS2) [MIM:603965]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
• Sequence similarities
  Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily.
  Contains 4 ANK repeats.
• Cellular localization
  Membrane.

• Target information above from: UniProt accession Q9Y210 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 407151 Cow
  • Entrez Gene: 7225 Human
  • Entrez Gene: 100271728 Pig
  • Omim: 603652 Human
  • SwissProt: Q9Y210 Human
  • Unigene: 159003 Human
• Alternative names
  • bZ1P14.9 antibody
  • FLJ11098 antibody
  • FLJ14863 antibody

  • FSGS2 antibody
  • MTRP6 antibody
  • Short transient receptor potential channel 6 antibody
  • si:rp71-1p14.9 antibody
  • Transient receptor potential cation channel subfamily C member 6 antibody
  • Transient receptor protein 6 antibody
  • TRP 6 antibody
  • TRP-6 antibody
  • TRP6 antibody
  • TRPC 6 antibody
  • Trpc6 antibody
  • TRPC6_HUMAN antibody
  • TRRP6 antibody

  see all

Protocols

• Western blot protocols