Overview

  • Product name
    Anti-TRPC6 antibody
    See all TRPC6 primary antibodies
  • Description
    Goat polyclonal to TRPC6
  • Host species
    Goat
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow, Pig
  • Immunogen

    Synthetic peptide corresponding to Human TRPC6 aa 918-931 (C terminal).
    Sequence:

    C-EKLSMEPNQEETNR


    Database link: Q9Y210

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control
    • Human placenta lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab106840 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab106840 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 110 kDa (predicted molecular weight: 106 kDa).

Target

  • Function
    Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
  • Tissue specificity
    Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.
  • Involvement in disease
    Defects in TRPC6 are the cause of focal segmental glomerulosclerosis type 2 (FSGS2) [MIM:603965]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
  • Sequence similarities
    Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily.
    Contains 4 ANK repeats.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
    • Alternative names
      • bZ1P14.9 antibody
      • FLJ11098 antibody
      • FLJ14863 antibody
      • FSGS2 antibody
      • MTRP6 antibody
      • Short transient receptor potential channel 6 antibody
      • si:rp71-1p14.9 antibody
      • Transient receptor potential cation channel subfamily C member 6 antibody
      • Transient receptor protein 6 antibody
      • TRP 6 antibody
      • TRP-6 antibody
      • TRP6 antibody
      • TRPC 6 antibody
      • Trpc6 antibody
      • TRPC6_HUMAN antibody
      • TRRP6 antibody
      see all

    Images

    • Western blot - TRPC6 antibody (ab106840)
      Western blot - TRPC6 antibody (ab106840)
      Anti-TRPC6 antibody (ab106840) at 0.03 µg/ml + Human placenta lysate in RIPA buffer at 35 µg

      Developed using the ECL technique.

      Predicted band size: 106 kDa



      Primary incubation was 1 hour.

    References

    ab106840 has not yet been referenced specifically in any publications.

    Publishing research using ab106840? Please let us know so that we can cite the reference in this datasheet.

    Customer reviews and Q&As

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    1 Review or Q&A

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    Votes: Highest First

    I am interested in purchasing trpc6 antibody for FACS with human cells.  Do you sell such an antibody? Thanks

    Thank you very much for your interest in our anti-TRPC6 antibodies.

    While we do offer six products which work in human tissues, to our knowledge, none of these products have been tested in FACS on human cells. Therefore, I can offer a discoun...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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