Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • Additional sequence information14 amino acids near the amino terminus of human TRPC6.

Associated products

Specifications

Our Abpromise guarantee covers the use of ab106953 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-TRPC6 antibody (ab62461)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • bZ1P14.9
    • FLJ11098
    • FLJ14863
    • FSGS2
    • MTRP6
    • Short transient receptor potential channel 6
    • si:rp71-1p14.9
    • Transient receptor potential cation channel subfamily C member 6
    • Transient receptor protein 6
    • TRP 6
    • TRP-6
    • TRP6
    • TRPC 6
    • Trpc6
    • TRPC6_HUMAN
    • TRRP6
    see all
  • FunctionThought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
  • Tissue specificityExpressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.
  • Involvement in diseaseDefects in TRPC6 are the cause of focal segmental glomerulosclerosis type 2 (FSGS2) [MIM:603965]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
  • Sequence similaritiesBelongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily.
    Contains 4 ANK repeats.
  • Cellular localizationMembrane.
  • Information by UniProt

References for TRPC6 peptide (ab106953)

ab106953 has not yet been referenced specifically in any publications.

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