Overview

  • Product nameAnti-TRPM4 antibody
    See all TRPM4 primary antibodies
  • Description
    Rabbit polyclonal to TRPM4
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 1120-1149 of Human TRPM4 (NP_001182156.1, NP_060106.2).

  • Positive control
    • 293 cell line lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab124239 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 134 kDa.

Target

  • FunctionCalcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
  • Tissue specificityWidely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells.
  • Involvement in diseaseDefects in TRPM4 are the cause of progressive familial heart block type 1B (PFHB1B) [MIM:604559]. It is a cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrio-ventricular block causing syncope and sudden death.
  • Sequence similaritiesBelongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM4 sub-subfamily.
  • Post-translational
    modifications
    Phosphorylation by PKC leads to increase the sensitivity to Ca(2+).
    Sumoylated. Desumoylated by SENP1.
  • Cellular localizationEndoplasmic reticulum. Golgi apparatus and Cell membrane. Endoplasmic reticulum. Golgi apparatus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 1110030C19Rik antibody
    • AW047689 antibody
    • Calcium-activated non-selective cation channel 1 antibody
    • FLJ20041 antibody
    • hTRPM4 antibody
    • Long transient receptor potential channel 4 antibody
    • LTrpC-4 antibody
    • LTrpC4 antibody
    • Melastatin 4 antibody
    • Melastatin like 2 protein antibody
    • Melastatin-4 antibody
    • Melastatin-like 2 antibody
    • Mls2s antibody
    • PFHB1B antibody
    • Transient receptor potential cation channel subfamily M member 4 antibody
    • Transient receptor potential cation channel, subfamily M, member 4 antibody
    • Trpm4 antibody
    • TRPM4_HUMAN antibody
    • TRPM4B antibody
    see all

Anti-TRPM4 antibody images

  • Anti-TRPM4 antibody (ab124239) at 1/100 dilution + 293 cell line lysates at 35 µg

    Predicted band size : 134 kDa

References for Anti-TRPM4 antibody (ab124239)

ab124239 has not yet been referenced specifically in any publications.

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