Overview

  • Product name
    Anti-truncated GARP antibody
  • Description
    Rabbit polyclonal to truncated GARP
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Cow
  • Immunogen

    Synthetic peptide corresponding to Cow truncated GARP aa 287-299.
    Sequence:

    CDVQTRVVAAGSL


    (Peptide available as ab39811)

  • Positive control
    • Rat purified rod outer membranes.

Properties

Applications

Our Abpromise guarantee covers the use of ab15094 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 68 kDa).Can be blocked with Cow truncated GARP peptide (ab39811).

Target

  • Relevance
    Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. It forms a subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. There are 3 isoforms produced by alternative splicing. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties; it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Defects in GARP are the cause of retinitis pigmentosa type 25 (RP25). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • Cellular localization
    Membrane; Multi-pass membrane protein.
  • Database links
  • Alternative names
    • 240 kDa protein of rod photoreceptor CNG channel antibody
    • cGMP gated cation channel beta subunit antibody
    • CNCG 4 antibody
    • CNCG2 antibody
    • CNCG3L antibody
    • CNCG4 antibody
    • CNG 4 antibody
    • CNG channel 4 antibody
    • CNG channel beta 1 antibody
    • CNG4 antibody
    • CNGB 1 antibody
    • CNGB1 antibody
    • CNGB1B antibody
    • Cyclic nucleotide gated cation channel 4 antibody
    • Cyclic nucleotide gated cation channel antibody
    • Cyclic nucleotide gated cation channel beta 1 antibody
    • Cyclic nucleotide gated cation channel gamma antibody
    • Cyclic nucleotide gated cation channel modulatory subunit antibody
    • Cyclic nucleotide gated channel (photoreceptor) cGMP gated 3 (gamma) like antibody
    • Cyclic nucleotide gated channel beta 1 antibody
    • GAR1 antibody
    • GARP antibody
    • GARP2 antibody
    • Glutamic acid rich protein antibody
    • RCNC2 antibody
    • RCNCb antibody
    • RCNCbeta antibody
    • RP45 antibody
    • Truncated glutamic acid rich protein antibody
    • Truncated rod photoreceptor cGMP gated channel beta subunit antibody
    see all

Images



  • Predicted band size : 68 kDa

    Western blot of  truncated GARP in rat purified rod outer membranes using ab15094.

References

ab15094 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab15094.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up