Anti-TSH antibody (ab64378)
Key features and details
- Rabbit polyclonal to TSH
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-TSH antibody -
Description
Rabbit polyclonal to TSH -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Full length native protein (purified) corresponding to Human TSH.
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Positive control
- Human anterior pituitary tissue
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General notes
Cytoplasmic staining pattern
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab64378 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/200.
|
Notes |
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IHC-P
1/200. |
Target
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Relevance
Thyroid stimulating hormone, also known as thyrotropin, is secreted from cells in the anterior pituitary called thyrotrophs, finds its receptors on epithelial cells in the thyroid gland, and stimulates that gland to synthesize and release thyroid hormones. TSH is a glycoprotein hormone composed of two subunits which are non covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity. -
Cellular localization
Secreted -
Database links
- Entrez Gene: 1081 Human
- Entrez Gene: 7252 Human
- Omim: 118850 Human
- Omim: 188540 Human
- SwissProt: P01215 Human
- SwissProt: P01222 Human
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Alternative names
- CG ALPHA antibody
- CGA antibody
- Chorionic gonadotropin alpha polypeptide antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab64378 has been referenced in 1 publication.
- Mathioudakis N et al. Expression of the pituitary stem/progenitor marker GFRa2 in human pituitary adenomas and normal pituitary. Pituitary 18:31-41 (2015). PubMed: 24402129