Overview

  • Product nameAnti-TSH antibody [TSH-116]
    See all TSH primary antibodies
  • Description
    Mouse monoclonal [TSH-116] to TSH
  • SpecificityReacts with human thyroid stimulating hormone with association constant 1.1 x 1011 l/mol. The following cross-reactivities, expressed as binding of labelled hormone (% of total), were determined by solid phase RIA with excess of this antibody: hTSH = 78.9 hCG = 20.3 hLH = 23.2 hFSH = 29.9
  • Tested applicationsSuitable for: ELISA, RIAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native protein (purified) (Human).

Properties

Applications

Our Abpromise guarantee covers the use of ab767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
RIA
  • Application notesELISA: Use at an assay dependant concentration.
    RIA: Use at an assay dependant concentration.
    This antibody was used in combination with ab7906 for immunometric assays in the screening of neonatal hypothyroidism.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceThyroid stimulating hormone, also known as thyrotropin, is secreted from cells in the anterior pituitary called thyrotrophs, finds its receptors on epithelial cells in the thyroid gland, and stimulates that gland to synthesize and release thyroid hormones. TSH is a glycoprotein hormone composed of two subunits which are non covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity.
    • Cellular localizationSecreted
    • Database links
    • Alternative names
      • CG ALPHA antibody
      • CGA antibody
      • Chorionic gonadotropin alpha polypeptide antibody
      • FSHA antibody
      • Glycoprotein hormones alpha polypeptide antibody
      • GPHA1 antibody
      • Thyroid stimulating hormone beta subunit antibody
      • Thyrotropin beta subunit antibody
      • TSH beta antibody
      • TSHA antibody
      • TSHB antibody
      see all

    References for Anti-TSH antibody [TSH-116] (ab767)

    This product has been referenced in:
    • Jirkalova V  et al. Immunoradiometric and luminescence immunoenzymometric assay of human thyrotropin from dried blood spots for screening of neonatal hypothyroidism. Eur J Clin Chem Clin Biochem 34:823-7 (1996). Read more (PubMed: 8933106) »

    See 1 Publication for this product

    Product Wall

    Thank you for contacting us. We have following anti TSH products avialable in catalogue. ab116625: http://www.abcam.com/TSH-antibody-Fc1003-ab116625.html ab30796; http://www.abcam.com/TSH-antibody-ab30796.html ab767; http://www.abcam.co...

    Read More

    Unfortunately the epitope of ab7906 and ab767 is not known, just the fact that the two antibodies recognize different epitopes of TSH.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"