Overview

  • Product nameAnti-TSPAN12 antibody
    See all TSPAN12 primary antibodies
  • Description
    Rabbit polyclonal to TSPAN12
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 180-229 (SCCVREFPGC SKQAHQEDLS DLYQEGCGKK MYSFLRGTKQ LQVLRFLGIS) of Human TSPAN12 (NP_036470).

  • Positive control
    • Human fetal thymus lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab90091 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 35 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • RelevanceTSPAN12 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. It is a regulator of cell surface receptor signal transduction and plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. It acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. It also acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. It activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP) and activates MMP14/MT1-MMP-dependent cleavage activity.
  • Cellular localizationCell membrane; Multi-pass membrane protein.
  • Database links
  • Alternative names
    • 9030619E17 antibody
    • AI426782 antibody
    • AI663988 antibody
    • AW111457 antibody
    • MGC109305 antibody
    • NET 2 antibody
    • NET2 antibody
    • OTTHUMP00000211224 antibody
    • Tetraspan NET 2 antibody
    • Tetraspanin 12 antibody
    • Tetraspanin12 antibody
    • TM4SF12 antibody
    • Transmembrane 4 superfamily member 12 antibody
    • TSPAN 12 antibody
    see all

Anti-TSPAN12 antibody images

  • Anti-TSPAN12 antibody (ab90091) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal thymus lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 35 kDa

References for Anti-TSPAN12 antibody (ab90091)

ab90091 has not yet been referenced specifically in any publications.

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