Overview

  • Product nameAnti-TSPYL1 antibody
    See all TSPYL1 primary antibodies
  • Description
    Rabbit polyclonal to TSPYL1
  • Tested applicationsSuitable for: IHC-P, ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: AEEVKTGKCA TVSAAVAERE SAEVVVKEGL AEKEVMEEQM EVEEQPPEGE EIEVAEEDRL EEEAREEEGP WPLHEALRMD PLE, corresponding to amino acids of Human TSPYL1.

  • Positive control
    • Human kidney tissue; U 2 OS cells; RT 4, U 251 MG, Human liver and tonsil lysates.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferpH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab122200 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/1000 - 1/2500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml. Fixation/Permeabilization: PFA/Triton X-100
WB 1/250 - 1/500.

Target

  • Tissue specificityExpressed in testis, ovary, liver, spleen, brain, kidney, prostate, lung, liver, and heart.
  • Involvement in diseaseDefects in TSPYL1 are the cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT) [MIM:608800]. SIDDT is an autosomal recessive disorder. Affected infants appear normal at birth, develop signs of visceroautonomic dysfunction early in life, and die before 12 months of age of abrupt cardiorespiratory arrest. Features included bradycardia, hypothermia, severe gastroesophageal reflux, laryngospasm, bronchospasm, and abnormal cardiorespiratory patterns during sleep. Genotypic males with SIDDT had fetal testicular dysgenesis and ambiguous genitalia, with findings such as intraabdominal testes, dysplastic testes, deficient fetal testosterone production, fusion and rugation of the gonadal sac, and partial development of the penile shaft. Female sexual development was normal. Affected infants had an unusual staccato cry, similar to the cry of a goat.
  • Sequence similaritiesBelongs to the nucleosome assembly protein (NAP) family.
  • Cellular localizationNucleus > nucleolus.
  • Information by UniProt
  • Database links
  • Alternative names
    • SIDDT antibody
    • Testis specific like protein Y encoded antibody
    • Testis specific Y encoded like protein 1 antibody
    • Testis-specific Y-encoded-like protein 1 antibody
    • TSPY like antibody
    • TSPY like 1 antibody
    • TSPY like protein 1 antibody
    • TSPY-like protein 1 antibody
    • TSPYL antibody
    • TSPYL1 antibody
    • TSYL1_HUMAN antibody
    see all

Anti-TSPYL1 antibody images

  • ab122200, at 1/1000 dilution, staining TSPYL1 in paraffin-embedded Human kidney tissue by Immunohistochemistry.
  • ab122200, at 4 µg/ml, staining TSPYL1 in PFA/Triton X-100 fixed/permeabilized U 2 OS cells by Immunofluorescence (green).
  • All lanes : Anti-TSPYL1 antibody (ab122200) at 1/250 dilution

    Lane 1 : RT 4 lysate
    Lane 2 : U 251 MG lysate
    Lane 3 : Human plasma lysate
    Lane 4 : Human liver lysate
    Lane 5 : Human tonsil lysate

    Developed using the ECL technique

References for Anti-TSPYL1 antibody (ab122200)

ab122200 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab122200.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"