Overview

  • Product nameAnti-TSSC3 antibody
    See all TSSC3 primary antibodies
  • Description
    Rabbit polyclonal to TSSC3
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide derived from an internal region of Human TSSC3.

  • Positive control
    • Human placenta tissue.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab110935 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionPlays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.
  • Tissue specificityExpressed in placenta and adult prostate gland. In placenta, it is present in all cells of the villous cytotrophoblast. The protein is absent in cells from hydatidiform moles. Hydatidiform mole is a gestation characterized by abnormal development of both fetus and trophoblast. The majority of hydatidiform moles are associated with an excess of paternal to maternal genomes and are likely to result from the abnormal expression of imprinted genes (at protein level). Expressed at low levels in adult liver and lung, and fetal liver. Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines.
  • Sequence similaritiesBelongs to the PHLDA2 family.
    Contains 1 PH domain.
  • DomainThe PH domain binds phosphoinositides with a broad specificity. It may compete with the PH domain of some other proteins, thereby interfering with their binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3).
  • Cellular localizationCytoplasm. Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Beckwith Wiedemann syndrome chromosome region 1 candidate protein C antibody
    • Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein antibody
    • BRW 1C antibody
    • BRW1C antibody
    • BWR 1C antibody
    • BWR1C antibody
    • HLDA 2 antibody
    • HLDA2 antibody
    • Imprinted in placenta and liver antibody
    • Imprinted in placenta and liver protein antibody
    • IPL antibody
    • p17 Beckwith Wiedemann region 1C antibody
    • p17 BWR1C antibody
    • p17-Beckwith-Wiedemann region 1 C antibody
    • p17-BWR1C antibody
    • PHLA2_HUMAN antibody
    • PHLDA 2 antibody
    • phlda2 antibody
    • Pleckstrin homology like domain family A member 2 antibody
    • Pleckstrin homology-like domain family A member 2 antibody
    • TSSC 3 antibody
    • Tumor suppressing STF cDNA 3 protein antibody
    • Tumor suppressing subchromosomal transferable fragment candidate gene 3 protein antibody
    • Tumor suppressing subchromosomal transferable fragment cDNA 3 antibody
    • Tumor suppressing subtransferable candidate 3 antibody
    • Tumor supressing STF cDNA 3 antibody
    • Tumor-suppressing STF cDNA 3 protein antibody
    • Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein antibody
    see all

Anti-TSSC3 antibody images

  • ab110935, at a 1/50 dilution, staining TSSC3 in paraffin-embedded Human placenta tissue by Immunohistochemistry, in the absence (left) and presence (right) of the immunizing peptide.

References for Anti-TSSC3 antibody (ab110935)

ab110935 has not yet been referenced specifically in any publications.

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