Overview

  • Product nameAnti-TSSC3 antibody
    See all TSSC3 primary antibodies
  • Description
    Rabbit polyclonal to TSSC3
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 102-151 (QNRRALQDFR SRQERTAPAA PAEDAVAAAA AAPSEPSEPS RPSPQPKPRT) of Human TSSC3 (NP_003302).

  • Positive control
    • HT1080 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab99209 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 17 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P 1/100.

Target

  • FunctionPlays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.
  • Tissue specificityExpressed in placenta and adult prostate gland. In placenta, it is present in all cells of the villous cytotrophoblast. The protein is absent in cells from hydatidiform moles. Hydatidiform mole is a gestation characterized by abnormal development of both fetus and trophoblast. The majority of hydatidiform moles are associated with an excess of paternal to maternal genomes and are likely to result from the abnormal expression of imprinted genes (at protein level). Expressed at low levels in adult liver and lung, and fetal liver. Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines.
  • Sequence similaritiesBelongs to the PHLDA2 family.
    Contains 1 PH domain.
  • DomainThe PH domain binds phosphoinositides with a broad specificity. It may compete with the PH domain of some other proteins, thereby interfering with their binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3).
  • Cellular localizationCytoplasm. Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Beckwith Wiedemann syndrome chromosome region 1 candidate protein C antibody
    • Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein antibody
    • BRW 1C antibody
    • BRW1C antibody
    • BWR 1C antibody
    • BWR1C antibody
    • HLDA 2 antibody
    • HLDA2 antibody
    • Imprinted in placenta and liver antibody
    • Imprinted in placenta and liver protein antibody
    • IPL antibody
    • p17 Beckwith Wiedemann region 1C antibody
    • p17 BWR1C antibody
    • p17-Beckwith-Wiedemann region 1 C antibody
    • p17-BWR1C antibody
    • PHLA2_HUMAN antibody
    • PHLDA 2 antibody
    • phlda2 antibody
    • Pleckstrin homology like domain family A member 2 antibody
    • Pleckstrin homology-like domain family A member 2 antibody
    • TSSC 3 antibody
    • Tumor suppressing STF cDNA 3 protein antibody
    • Tumor suppressing subchromosomal transferable fragment candidate gene 3 protein antibody
    • Tumor suppressing subchromosomal transferable fragment cDNA 3 antibody
    • Tumor suppressing subtransferable candidate 3 antibody
    • Tumor supressing STF cDNA 3 antibody
    • Tumor-suppressing STF cDNA 3 protein antibody
    • Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein antibody
    see all

Anti-TSSC3 antibody images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human bronchial epithelial tissue labelling TSSC3 with ab99209 at 1/100. A Cy3-conjugate donkey anti-rabbit IgG (1/200) was used as the secondary antibody. Positive staining shown in the cytoplasm and membrane. Magnification: 20X. Exposure time: 0.5 - 2.0 seconds. Left - DAPI. Middle - TSSC3. Right - Merge.
  • Anti-TSSC3 antibody (ab99209) at 1 µg/ml + HT1080 cell lysate at 10 µg

    Predicted band size : 17 kDa
    Gel concentration 10-20%

References for Anti-TSSC3 antibody (ab99209)

This product has been referenced in:
  • Dai H  et al. TSSC3 overexpression associates with growth inhibition, apoptosis induction and enhances chemotherapeutic effects in human osteosarcoma. Carcinogenesis : (2011). WB ; Human . Read more (PubMed: 22021909) »

See 1 Publication for this product

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