Overview

  • Product name
    Anti-TTC37 antibody
  • Description
    Rabbit polyclonal to TTC37
  • Tested applications
    Suitable for: ICC/IF, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: QLGLTYWFMG EETRKDKTKA LTHFLKAARL DTYMGKVFCY LGHYYRDVVG DKNRARGCYR KAFELDDTDA ESGAAAVDLS VELEDMEMAL AILTTVTQK, corresponding to amino acids 459-557 of Human TTC37.

  • Positive control
    • Human stomach tissue

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab122421 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Tissue specificity
    Widely expressed with the highest levels observed in vascular tissues, lymph node, pituitary, lung and intestine. Not expressed in the liver.
  • Involvement in disease
    Note=Defects in TTC37 are associated with Trico-Hepato-Enteric syndrome (THE). THE syndrome is a rare and severe autosonmal recessive condition that associates intractable diarrhea with facial dysmorphism, intrauterine growth retardation immunodeficiency with low serum concentrations of immunoglobulins and hair abnormalities characterized by woolly hair.
  • Sequence similarities
    Contains 20 TPR repeats.
  • Information by UniProt
  • Database links
  • Alternative names
    • KIAA0372 antibody
    • Tetratricopeptide repeat protein 37 antibody
    • Thespin antibody
    • TPR repeat protein 37 antibody
    • TTC37 antibody
    • TTC37_HUMAN antibody
    see all

Images

  • Immunofluorescent staining of Human cell line A-431 shows positivity in nucleus but not nucleoli and cytoplasm. Recommended concentration of ab122421 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab122421 at 1/35 dilution staining TTC37 in Paraffin-embedded Human stomach tissue by Immunohistochemistry.

References

This product has been referenced in:

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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