Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA).
Defects in TTDN1 are a cause of nonphotosensitive trichothiodystrophy (TTD), also known as Amish brittle hair brain syndrome (ABHS), hair-brain syndrome and BIDS syndrome. TTD is an autosomal recessive disorder characterized by short stature, intellectual impairment, sulfur deficient brittle hair and decreased male fertility, but not cutaneous photosensitivity.
Kuschal C et al. GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy. Am J Hum Genet98:627-42 (2016).
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