Potent and selective pan RAR agonist. Retinoic acid (ab141023, ab120728) analog. Binds with high affinity to RAR α, β, and γ subtypes but does not bind to PPARδ. Shows antihyperkeratotic effects in vivo.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Oeda S et al. Induction of intermediate mesoderm by retinoic acid receptor signaling from differentiating mouse embryonic stem cells. Int J Dev Biol57:383-9 (2013).
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Murholm M et al. Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes. BMC Cell Biol14:41 (2013).
Read more (PubMed: 24059847) »
Pignatello MA et al. Multiple factors contribute to the toxicity of the aromatic retinoid, TTNPB (Ro 13-7410): binding affinities and disposition. Toxicol Appl Pharmacol142:319-27 (1997).
Read more (PubMed: 9070355) »