Overview

  • Product name
    TTNPB (Arotinoid Acid)
  • Description
    Potent and selective RAR agonist
  • Biological description
    Potent and selective pan RAR agonist. Retinoic acid (ab141023, ab120728) analog. Binds with high affinity to RAR α, β, and γ subtypes but does not bind to PPARδ. Shows antihyperkeratotic effects in vivo.
  • Purity
    > 99%

Properties

  • Chemical name
    4-[(1E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propen-1-yl]benzoic acid
  • Molecular weight
    348.48
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C24H28O2
  • CAS Number
    71441-28-6
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Oeda S  et al. Induction of intermediate mesoderm by retinoic acid receptor signaling from differentiating mouse embryonic stem cells. Int J Dev Biol 57:383-9 (2013). Read more (PubMed: 23873370) »
  • Murholm M  et al. Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes. BMC Cell Biol 14:41 (2013). Read more (PubMed: 24059847) »
  • Pignatello MA  et al. Multiple factors contribute to the toxicity of the aromatic retinoid, TTNPB (Ro 13-7410): binding affinities and disposition. Toxicol Appl Pharmacol 142:319-27 (1997). Read more (PubMed: 9070355) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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