• Product name
  • Description
    Rabbit polyclonal to TUBA8
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 32-81 (ADGTFGTQAS KINDDDSFTT FSETGNGKHV RAVMVDLEPT VDEVRAG) of Mouse TUBA8 (NP_059075).

  • Positive control
    • Mouse spleen lysate


  • Form
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Constituents: 98% PBS, 2% Sucrose
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab113921 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 50 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • Function
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
  • Tissue specificity
    Preferentially expressed in heart, skeletal muscle and testis. Expressed at low levels in the developing brain.
  • Involvement in disease
    Defects in TUBA8 are the cause of polymicrogyria with optic nerve hypoplasia (PMGONH) [MIM:613180]. It is a disease characterized by extensive polymicrogyria, optic nerve hypoplasia, severe developmental delay, hypotonia, seizures, a dysplastic or absent corpus callosum and colpocephaly. Polymicrogyria is a malformation of the cortex in which the brain surface is irregular and characterized by an excessive number of small gyri with abnormal lamination.
  • Sequence similarities
    Belongs to the tubulin family.
  • Post-translational
    Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.
  • Cellular localization
    Cytoplasm > cytoskeleton.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alpha tubulin 8 antibody
    • Alpha-tubulin 8 antibody
    • TBA8_HUMAN antibody
    • Tuba8 antibody
    • TUBAL2 antibody
    • Tubulin alpha 8 chain antibody
    • Tubulin alpha chain like 2 antibody
    • Tubulin alpha chain-like 2 antibody
    • Tubulin alpha-8 chain antibody
    see all

Anti-TUBA8 antibody images

  • Anti-TUBA8 antibody (ab113921) at 1 µg/ml + Mouse spleen lysate at 10 µg

    Predicted band size : 50 kDa

References for Anti-TUBA8 antibody (ab113921)

ab113921 has not yet been referenced specifically in any publications.

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