Overview

  • Product nameAnti-TUBB2A antibody
    See all TUBB2A primary antibodies
  • Description
    Rabbit polyclonal to TUBB2A
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 409-438 of Human TUBB2A (NP_001060.1).

  • Positive control
    • 293 cell line lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab116372 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.

Target

  • FunctionTubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
  • Sequence similaritiesBelongs to the tubulin family.
  • Post-translational
    modifications
    Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.
  • Cellular localizationCytoplasm > cytoskeleton.
  • Information by UniProt
  • Database links
  • Alternative names
    • Class IIa beta tubulin antibody
    • dJ40E16.7 antibody
    • M(beta)2 antibody
    • TBB2A_HUMAN antibody
    • TUBB antibody
    • TUBB2 antibody
    • Tubb2a antibody
    • Tubulin beta 2 antibody
    • Tubulin beta 2A antibody
    • Tubulin beta 2A class IIa antibody
    • Tubulin beta polypeptide 2 antibody
    • Tubulin beta polypeptide antibody
    • Tubulin beta-2A chain antibody
    see all

Anti-TUBB2A antibody images

  • Anti-TUBB2A antibody (ab116372) at 1/100 dilution + 293 cell line lysate at 35 µg

    Predicted band size : 50 kDa

References for Anti-TUBB2A antibody (ab116372)

ab116372 has not yet been referenced specifically in any publications.

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