Overview

  • Product nameAnti-TUBB6 antibody
    See all TUBB6 primary antibodies
  • Description
    Rabbit polyclonal to TUBB6
  • SpecificityThe peptide used as the immunogen for the antibody is from Human TUBB6. The immunogen sequence suggests this antibody may cross-react with TUBB 1-5, although we have not tested this.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A KLH conjugated synthetic peptide between 146-174 amino acids from the central region of Human TUBB6 (NP_115914.1).

  • Positive control
    • K562 cell line lysates

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage bufferPreservative: 0.09% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • PurityProtein A purified
  • Purification notesThis antibody is purified through a protein A column, followed by peptide affinity purification.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab110592 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.

Target

  • FunctionTubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
  • Sequence similaritiesBelongs to the tubulin family.
  • DomainThe highly acidic C-terminal region may bind cations such as calcium.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
    Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.
  • Cellular localizationCytoplasm > cytoskeleton.
  • Information by UniProt
  • Database links
  • Alternative names
    • tubulin beta-6 chain-like antibody
    • class V beta-tubulin antibody
    • HsT1601 antibody
    • TBB6_HUMAN antibody
    • TUBB-5 antibody
    • TUBB6 antibody
    • Tubulin beta 6 chain antibody
    • tubulin beta 6 class V antibody
    • tubulin beta class V antibody
    • tubulin beta MGC4083 antibody
    • Tubulin beta-6 antibody
    • Tubulin beta-6 chain antibody
    see all

Anti-TUBB6 antibody images

  • Anti-TUBB6 antibody (ab110592) at 1/100 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 50 kDa

References for Anti-TUBB6 antibody (ab110592)

ab110592 has not yet been referenced specifically in any publications.

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