Anti-Tubulin Polymerization Promoting Protein antibody (ab48731)

Overview

  • Product nameAnti-Tubulin Polymerization Promoting Protein antibody
    See all Tubulin Polymerization Promoting Protein primary antibodies
  • Description
    Rabbit polyclonal to Tubulin Polymerization Promoting Protein
  • SpecificityThis antibody recognizes 2900041A09Rik
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Chicken, Cow, Dog, Pig
  • Immunogen

    Synthetic peptide: FTGSHKERFD QSGKGKGKAG RVDLVDESGY VPGYKHAGTY DQKVQGGK, corresponding to C terminal amino acids 171-218 of Mouse Tubulin Polymerization Promoting Protein

  • Positive control
    • Brain lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab48731 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1.25 µg/ml. Detects a band of approximately 24 kDa (predicted molecular weight: 24 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionMay play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.
  • Tissue specificityWidely expressed.
  • Sequence similaritiesBelongs to the TPPP family.
  • Post-translational
    modifications
    Poor substrate for GSK3 (By similarity). Phosphorylated by LIMK1 on serine residues. Phosphorylation may alter the tubulin polymerization activity.
  • Cellular localizationCytoplasm. Cytoplasm, cytoskeleton. Nucleus. Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies.
  • Information by UniProt
  • Database links
  • Alternative names
    • 25 kDa brain specific protein antibody
    • 25 kDa brain-specific protein antibody
    • Brain specific protein p25 alpha antibody
    • Glycogen synthase kinase 3 (GSK3) inhibitor p24 antibody
    • OTTHUMP00000161630 antibody
    • p24 antibody
    • p25 antibody
    • p25-alpha antibody
    • p25alpha antibody
    • TPPP antibody
    • TPPP/p25 antibody
    • TPPP_HUMAN antibody
    • TPPP1 antibody
    • Tubulin polymerization promoting protein antibody
    • Tubulin polymerization-promoting protein antibody
    see all

Anti-Tubulin Polymerization Promoting Protein antibody images

  • Anti-Tubulin Polymerization Promoting Protein antibody (ab48731) at 1.25 µg/ml + Brain lysate at 10 µg with 5% skimmed milk in PBS

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 24 kDa
    Observed band size : 24 kDa

References for Anti-Tubulin Polymerization Promoting Protein antibody (ab48731)

ab48731 has not yet been referenced specifically in any publications.

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