This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Involvement in disease
Combined oxidative phosphorylation deficiency 4 (COXPD4) [MIM:610678]: A mitochondrial disease resulting in neonatal lactic acidosis, rapidly progressive encephalopathy, severely decreased mitochondrial protein synthesis, and combined deficiency of mtDNA-related mitochondrial respiratory chain complexes. Note=The disease is caused by mutations affecting the gene represented in this entry.
Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.
Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells labeling TUFM using ab155328 at 1/500 dilution (green). Alpha tubulin filaments were labeled with an Alpha tubulin antibody at 1/2500 dilution (red).
Roselló-Lletí E et al. Heart mitochondrial proteome study elucidates changes in cardiac energy metabolism and antioxidant PRDX3 in human dilated cardiomyopathy. PLoS One9:e112971 (2014).
Read more (PubMed: 25397948) »