Overview

  • Product nameAnti-TULP1 antibody
    See all TULP1 primary antibodies
  • Description
    Rabbit polyclonal to TULP1
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment containing a sequence corresponding to a region within amino acids 281-520 of Human TULP1 (NP_003313).

  • Positive control
    • 293T, A431, H1299, HeLaS3, HepG2, Molt-4 and Raji whole cell lysates; Breast CA

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab97281 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 61 kDa.
IHC-P 1/100 - 1/250.

Target

  • FunctionRequired for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.
  • Tissue specificityRetina-specific.
  • Involvement in diseaseDefects in TULP1 are the cause of retinitis pigmentosa type 14 (RP14) [MIM:600132]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP14 inheritance is autosomal recessive.
    Defects in TULP1 are the cause of Leber congenital amaurosis type 15 (LCA15) [MIM:613843]. LCA15 is a severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus.
  • Sequence similaritiesBelongs to the TUB family.
  • Cellular localizationCytoplasm. Cell membrane. Secreted. Cell junction > synapse. Detected at synapses between photoreceptor cells and second-order neurons. Does not have a cleavable signal peptide and is secreted by an alternative pathway.
  • Information by UniProt
  • Database links
  • Alternative names
    • RP14 antibody
    • Tubby like protein 1 antibody
    • Tubby related protein 1 (Tubby like protein 1) antibody
    • Tubby related protein 1 antibody
    • Tubby-like protein 1 antibody
    • Tubby-related protein 1 antibody
    • TUBL1 antibody
    • TULP 1 antibody
    • Tulp1 antibody
    • TULP1_HUMAN antibody
    see all

Anti-TULP1 antibody images

  • All lanes : Anti-TULP1 antibody (ab97281) at 1/1000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : A431 whole cell lysate
    Lane 3 : H1299 whole cell lysate
    Lane 4 : HeLa S3 whole cell lysate
    Lane 5 : HepG2 whole cell lysate
    Lane 6 : Molt-4 whole cell lysate
    Lane 7 : Raji whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 61 kDa
  • Immunohistochemical analysis of TULP1 in paraffin-embedded Breast CA, using ab97281 at 1/100 dilution.

References for Anti-TULP1 antibody (ab97281)

ab97281 has not yet been referenced specifically in any publications.

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