Anti-Tumor necrosis factor alpha-induced protein 8-like protein 2 antibody (ab110389)

Overview

  • Product nameAnti-Tumor necrosis factor alpha-induced protein 8-like protein 2 antibody
    See all Tumor necrosis factor alpha-induced protein 8-like protein 2 primary antibodies
  • Description
    Rabbit polyclonal to Tumor necrosis factor alpha-induced protein 8-like protein 2
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    A synthesized peptide derived from an internal region of Human Tumor necrosis factor alpha-induced protein 8-like protein 2.

  • Positive control
    • Extracts from HuvEc cells

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage bufferpH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 50% Glycerol, 0.88% Sodium chloride
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG

Applications

Our Abpromise guarantee covers the use of ab110389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 21 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. or using a pressure cooker for about 5 minutes.

Target

  • FunctionActs as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.
  • Sequence similaritiesBelongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
  • DomainThe central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.
  • Information by UniProt
  • Database links
  • Alternative names
    • AW610835 antibody
    • FLJ23467 antibody
    • Inflammation factor 20 antibody
    • Inflammation factor protein 20 antibody
    • TIPE2 antibody
    • TNF alpha-induced protein 8-like protein 2 antibody
    • TNFAIP8-like protein 2 antibody
    • TNFAIP8L2 antibody
    • TP8L2_HUMAN antibody
    • Tumor necrosis factor alpha induced protein 8 like 2 antibody
    • Tumor necrosis factor alpha-induced protein 8-like protein 2 antibody
    see all

Anti-Tumor necrosis factor alpha-induced protein 8-like protein 2 antibody images

  • All lanes : Anti-Tumor necrosis factor alpha-induced protein 8-like protein 2 antibody (ab110389) at 1/500 dilution

    Lane 1 : extracts from HuvEc cells
    Lane 2 : extracts from HuvEc cells with blocking peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 21 kDa

References for Anti-Tumor necrosis factor alpha-induced protein 8-like protein 2 antibody (ab110389)

ab110389 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"