Overview

  • Product nameAnti-TWEAK antibody [MTW-1] (Biotin)
    See all TWEAK primary antibodies
  • Description
    Rat monoclonal [MTW-1] to TWEAK (Biotin)
  • ConjugationBiotin
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Full length Mouse TWEAK.

  • Positive control
    • Mouse TWEAK transfected L5178Y cells

Properties

Applications

Our Abpromise guarantee covers the use of ab95626 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 0.125µg for 105-8 cells. A 100 µl volume is recommended for staining the cell sample.



ab18403-Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • FunctionBinds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.
  • Tissue specificityHighly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
  • Sequence similaritiesBelongs to the tumor necrosis factor family.
  • Post-translational
    modifications
    The soluble form derives from the membrane form by proteolytic processing.
  • Cellular localizationSecreted and Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • APO 3 ligand antibody
    • APO 3L antibody
    • APO3 ligand antibody
    • APO3/DR3 ligand antibody
    • APO3L antibody
    • DR3LG antibody
    • MGC129581 antibody
    • MGC20669 antibody
    • secreted form antibody
    • TNF-related weak inducer of apoptosis antibody
    • TNF12_HUMAN antibody
    • TNFSF 12 antibody
    • Tnfsf12 antibody
    • TNFSF12 protein antibody
    • Tumor necrosis factor (ligand) superfamily member 12 antibody
    • Tumor necrosis factor ligand superfamily member 12 antibody
    • Tumor necrosis factor superfamily member 12 antibody
    • TWEAK antibody
    • UNQ181/PRO207 antibody
    see all

Anti-TWEAK antibody [MTW-1] (Biotin) images

  • Staining of non-transfected (left) and TWEAK transfected (right) L5178Y cells with 0.06 µg of Rat IgG1 Isotype Control Biotin (open histogram) or 0.03 µg of ab95626 (filled histogram) followed by Streptavidin PE. Total viable cells were used for analysis.

References for Anti-TWEAK antibody [MTW-1] (Biotin) (ab95626)

This product has been referenced in:
  • Nakayama M  et al. Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies. Biochem Biophys Res Commun 306:819-25 (2003). Read more (PubMed: 12821115) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"