• Product nameAnti-TWEAKR antibody [ITEM-4]
    See all TWEAKR primary antibodies
  • Description
    Mouse monoclonal [ITEM-4] to TWEAKR
  • Tested applicationsSuitable for: Flow Cyt, WB, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Human Fn14 transfected P815.



Our Abpromise guarantee covers the use of ab21127 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 1µg for 106 cells. (in 100µl volume)

ab170192-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
WB Use at an assay dependent concentration. Predicted molecular weight: 27 kDa.
IHC-Fr Use at an assay dependent concentration.


  • FunctionReceptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
  • Tissue specificityHighly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.
  • Sequence similaritiesContains 1 TNFR-Cys repeat.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD 266 antibody
    • CD266 antibody
    • CD266 antigen antibody
    • FGF inducible 14 antibody
    • FGF-inducible 14 antibody
    • Fibroblast growth factor inducible immediate early response protein 14 antibody
    • Fibroblast growth factor-inducible immediate-early response protein 14 antibody
    • FN 14 antibody
    • FN14 antibody
    • TNFRSF 12A antibody
    • TNFRSF12A antibody
    • TNR12_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 12A antibody
    • TWEAK R antibody
    • Tweak receptor antibody
    • Tweak-receptor antibody
    • TweakR antibody
    see all

References for Anti-TWEAKR antibody [ITEM-4] (ab21127)

This product has been referenced in:
  • Polek TC  et al. TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor. J Biol Chem 278:32317-23 (2003). Read more (PubMed: 12794080) »

See 1 Publication for this product

Product Wall

Thank you for your enquiry.

According to the following Nature review on the TWEAK Fn14 signaling pathway, and other publications, I would suggest that if this TWEAK receptor antibody is indeed binding and blocking TWEAK receptor, then this w...

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Indeed, the epitope for the antibody ab21127 has not been mapped. However as this antibody stains the surface of the cell for TWEAK receptor in flow cytometry and no permeabilization is needed during staining the epitope must be extracellular.

Thank you for your enquiry. I apologize that our data sheet was a bit confusing, this antibody was made to the receptor, not the cytokine. I will be updating the data sheet today. I hope that this information helps, and please do not hesitate to co...

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