• Product name
  • Description
    Rabbit polyclonal to Twinkle
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide corresponding to a region within the internal sequence amino acids 612-661 (GDVGVFPLEF NKNSLTFSIP PKNKARLKKI KDDTGPVAKK PSSGKKGATT) of Human Twinkle (NP_068602)

  • Positive control
    • Jurkat cell lysate.



Our Abpromise guarantee covers the use of ab83207 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 77 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay: 1/62500.


  • Function
    Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals.
  • Tissue specificity
    High relative levels in skeletal muscle, testis and pancreas. Lower levels of expression in the heart, brain, placenta, lung, liver, kidney, spleen, thymus, prostate, ovary, small intestine, colon and leukocytes. Expression is coregulated with MRPL43.
  • Involvement in disease
    Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 3
    Sensory ataxic neuropathy dysarthria and ophthalmoparesis
    Mitochondrial DNA depletion syndrome 7
  • Sequence similarities
    Contains 1 SF4 helicase domain.
  • Cellular localization
    Mitochondrion matrix > mitochondrion nucleoid. Colocalizes with mtDNA in mitochondrial nucleoids, a nucleoproteins complex consisting of a number of copies of proteins associated with mtDNA, probably involved in mtDNA maintenance and expression.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ataxin 8 antibody
    • Ataxin8 antibody
    • ATXN 8 antibody
    • ATXN8 antibody
    • C10 orf2 antibody
    • C10orf 2 antibody
    • C10orf2 antibody
    • Chromosome 10 open reading frame 2 antibody
    • IOSCA antibody
    • mitochondrial antibody
    • MTDPS7 antibody
    • PEO 1 antibody
    • PEO antibody
    • PEO1 antibody
    • PEO1_HUMAN antibody
    • PEOA3 antibody
    • Progressive external ophthalmoplegia 1 protein antibody
    • SANDO antibody
    • SCA 8 antibody
    • SCA8 antibody
    • T7 gp4 like protein with intramitochondrial nucleoid localization antibody
    • T7 gp4-like protein with intramitochondrial nucleoid localization antibody
    • T7 helicase-related protein with intramitochondrial nucleoid localization antibody
    • T7 like mitochondrial DNA helicase antibody
    • T7-like mitochondrial DNA helicase antibody
    • Twinkle protein antibody
    • Twinkle protein, mitochondrial antibody
    • TWINL antibody
    see all


  • Anti-Twinkle antibody (ab83207) at 1 µg/ml + Jurkat cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 77 kDa
    Observed band size : 90 kDa (why is the actual band size different from the predicted?)


ab83207 has not yet been referenced specifically in any publications.

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