Anti-Two pore calcium channel protein 2 antibody (ab111145)

Overview

  • Product name
    Anti-Two pore calcium channel protein 2 antibody
    See all Two pore calcium channel protein 2 primary antibodies
  • Description
    Goat polyclonal to Two pore calcium channel protein 2
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH corresponding to a region within the C Terminal of Human Two pore calcium channel protein 2.

  • Positive control
    • Human colon and pancreas tissue

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab111145 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction.
  • Tissue specificity
    Widely expressed. Expressed at high level in liver and kidney.
  • Sequence similarities
    Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.
  • Domain
    Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Lysosome membrane. Only the acidic lysosomal fraction is sensitive to NAADP.
  • Information by UniProt
  • Database links
  • Alternative names
    • SHEP10 antibody
    • TPC2 antibody
    • TPC2_HUMAN antibody
    • tpcn2 antibody
    • Two pore calcium channel protein 2 antibody
    • two pore segment channel 2 antibody
    • Two-pore channel 2 antibody
    • Voltage dependent calcium channel protein TPC2 antibody
    • Voltage-dependent calcium channel protein TPC2 antibody
    see all

Images

  • ab111145, at 3.75 µg/ml, staining Two pore calcium channel protein 2 in formalin fixed, paraffin embedded Human colon tissue by Immunohistochemistry. Followed by biotinylated secondary antibody, alkaline phosphatase streptavidin and chromogen.
  • ab111145, at 3.75 µg/ml, staining Two pore calcium channel protein 2 in formalin fixed, paraffin embedded Human pancreas tissue by Immunohistochemistry. Followed by biotinylated secondary antibody, alkaline phosphatase streptavidin and chromogen.

References

ab111145 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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